Dinner

Effortless Chicken Bubble Biscuit Bake Casserole Recipe

ByOlivia Monroe November 25, 2025November 25, 2025

Introduction

This Effortless Chicken Bubble Biscuit Bake Casserole is a comforting, all-in-one meal perfect for busy weeknights. It combines tender chicken, creamy sauce, and fluffy biscuit pieces baked to golden perfection. Easy to prepare and packed with flavor, it’s sure to become a family favorite.

A white rectangular baking dish filled with a baked cheesy bread dish featuring a top layer of golden brown, crispy bread pieces with some melted cheese spots. The bread pieces are irregularly shaped with a rough texture and sprinkled with small green herb bits. A wooden spoon lifts one piece, showing a gooey, creamy white and light yellow cheese layer underneath, with cheese stretching between the spoon and the dish. The dish rests on a white marbled surface with a dark green cloth partially visible beneath it. Photo taken with an iphone --ar 4:5 --v 7

Ingredients

3 cups cooked chicken (shredded or diced)
1 can cream of chicken soup
1 cup sour cream (plain Greek yogurt can be used)
1/2 cup milk (chicken broth can enhance flavor)
2 cups frozen mixed vegetables
1 teaspoon garlic powder (fresh garlic can be used)
1 teaspoon onion powder
1 teaspoon salt
1/2 teaspoon pepper
1 can refrigerated biscuit dough (cut into quarters)
2 cups shredded cheese (cheddar or a blend of cheeses)
2 tablespoons melted butter (optional for brushing)

Instructions

Step 1: Preheat your oven to 350°F (175°C) and grease a 9×13-inch baking dish.
Step 2: Unroll the refrigerated biscuit dough and cut each biscuit into quarters.
Step 3: In a large mixing bowl, combine the shredded chicken, cream of chicken soup, sour cream, and milk. Add the frozen mixed vegetables, garlic powder, onion powder, salt, and pepper. Mix until smooth.
Step 4: Fold the quartered biscuit pieces into the chicken filling mixture.
Step 5: Pour the filling mixture into the greased baking dish and sprinkle with shredded cheese.
Step 6: Cover with aluminum foil and bake for 20 minutes. Remove foil and bake for another 10-15 minutes until biscuits are golden brown and cheese is bubbling.
Step 7: Allow to cool for about 5 minutes before serving.

Tips & Variations

For extra flavor, use chicken broth instead of milk and brush biscuits with melted butter before baking.
Swap frozen mixed vegetables for fresh or use your favorite single vegetable like peas or green beans.
Add herbs such as thyme or rosemary for a fragrant twist.
Use different cheese blends like Monterey Jack or mozzarella for varied cheesy flavor.

Storage

Store leftovers in an airtight container in the refrigerator for up to 3 days. Reheat portions in the microwave or oven until warmed through. For best texture, reheat in the oven to keep the biscuits crisp.

How to Serve

A white rectangular dish filled with a baked cheesy pull-apart bread, showing about two layers of fluffy, golden bread pieces with a crispy, browned cheese crust on top, dotted with small bits of green herbs. The bread pieces appear soft and airy inside, with melted creamy cheese stretching as a wooden spoon lifts a serving from the center. The cheese looks gooey and white-yellowish, with a slightly browned crust at the edges of the bread pieces. The dish rests on a white marbled surface with a blue cloth nearby. Photo taken with an iphone --ar 4:5 --v 7

Serve this delicious recipe with your favorite sides.

FAQs

Can I use fresh chicken instead of cooked chicken?

It’s best to use pre-cooked chicken for this recipe to ensure the casserole cooks evenly and the chicken stays moist. If using raw chicken, cook it thoroughly before mixing.

Can I make this casserole ahead of time?

Yes, you can assemble the casserole and refrigerate it uncovered or covered with foil for up to 24 hours before baking. Add a few extra minutes to the baking time if baking from cold.