Name: Spicy Southern Cheesy Chicken Spaghetti Casserole Recipe
Prep time: 20 min
Cook time: 30 min
Total time: 50 min
Cuisine: Southern
Ingredients: 3-4 boneless, skinless chicken breasts (about 1.5 lbs); 8 oz spaghetti; 2 cups shredded sharp cheddar cheese; 1 cup fresh bell peppers (chopped); 1 can (10.5 oz) cream of chicken soup; 1 tsp paprika; 1/2 tsp cayenne pepper; 1 tsp garlic powder; 1/4 cup green onions (sliced)

Jump to Recipe

There’s just something completely irresistible about a bubbling, cheesy casserole that comes straight out of the oven, especially when it’s packed with bold flavors and a little spicy kick — and that’s why I can never get enough of this Spicy Southern Cheesy Chicken Spaghetti Casserole. Between the tender strands of spaghetti, gooey cheddar, juicy chicken, and a peppery, creamy sauce, you get cozy comfort food with a sassy Southern edge in every bite. Whether you’re feeding a crowd or just want extra leftovers to savor, this casserole is packed with flavor, family appeal, and just the right hint of heat.

Spicy Southern Cheesy Chicken Spaghetti Casserole Recipe - Recipe Image

Ingredients You’ll Need

Don’t you just love when dinner comes together using familiar staples that each bring something special to the table? Every ingredient in this Spicy Southern Cheesy Chicken Spaghetti Casserole plays its part — whether it’s for flavor, color, or ooey-gooey satisfaction — so let’s break down what makes this dish so delightfully craveable.

Boneless, skinless chicken breasts: Go for 3-4 pieces (about 1.5 lbs); a quick pan-cook delivers juicy, flavorful bites in the casserole.
Spaghetti: Use 8 oz — cooked al dente to hold up in all that cheesy, creamy goodness.
Shredded sharp cheddar cheese: Two full cups — trust me, sharp cheddar gives the casserole its signature tang and glorious melt.
Fresh bell peppers (chopped): One cup brings lively color, crunch, and a fresh, bright contrast to the richness.
Cream of chicken soup: One can (10.5 oz); this is your shortcut to a velvety, flavorful sauce that coats every strand.
Paprika: Just 1 teaspoon for sweet depth and that gorgeous, golden color on top.
Cayenne pepper: A half teaspoon adds that Southern heat — adjust up or down if you’re feeling bold!
Garlic powder: One teaspoon ensures the whole casserole is infused with garlicky warmth (without any mincing involved).
Green onions (sliced): Don’t skip the 1/4 cup for garnish — they offer a snappy, fresh finish to every serving.

How to Make Spicy Southern Cheesy Chicken Spaghetti Casserole

Step 1: Prep Your Oven and Dish

Start by preheating your oven to 350°F (175°C) and give your large casserole dish a quick grease. This not only ensures your Spicy Southern Cheesy Chicken Spaghetti Casserole will pop out easily but also helps the edges caramelize for extra flavor — a small step that makes a big difference.

Step 2: Cook the Chicken to Juicy Perfection

Place those chicken breasts in a large pot or skillet, cooking them over medium heat for around 6-7 minutes on each side. You’ll want that beautiful golden sear and no pink in the center. Let them rest a couple of minutes, then shred or dice — bite-sized pieces make sure chicken is tucked into every cheesy forkful.

Step 3: Boil the Spaghetti

As the chicken cooks, bring a generous pot of salted water to a boil and toss in your spaghetti. Cook until just al dente, usually 8-10 minutes; remember, it’ll continue cooking in the oven, so keep it firm for best results. Drain and set aside.

Step 4: Mix Up the Casserole Base

In a large mixing bowl, combine the shredded chicken, cooked spaghetti, cream of chicken soup, chopped bell peppers, paprika, cayenne, garlic powder, and half your shredded cheddar. This glorious mixture is your flavor-packed foundation, so give it a good stir until everything’s coated and evenly mixed.

Step 5: Assemble and Bake

Spoon the mixture into your prepared casserole dish, pressing gently to spread it out. Scatter the remaining cheddar cheese generously on top (don’t be shy — this is the golden crown!). Slide the dish into the oven, letting it bake uncovered for 25-30 minutes, or until bubbly edges and a golden cheesy top call your name.

Step 6: Rest and Garnish

Once hot and bubbling, remove your Spicy Southern Cheesy Chicken Spaghetti Casserole and let it rest for five minutes. This short wait lets the flavors settle and makes every slice neater. Just before serving, sprinkle with plenty of chopped green onions for a crisp, colorful finish.

How to Serve Spicy Southern Cheesy Chicken Spaghetti Casserole

Garnishes

To really make your Spicy Southern Cheesy Chicken Spaghetti Casserole pop, finish each plate with a scattering of fresh green onions, maybe a dusting of extra paprika, or a handful of chopped fresh parsley. A little sprinkle of red pepper flakes is perfect for chili-lovers who want a touch more heat. These last-minute touches add color, extra freshness, and a little drama to your presentation.

Side Dishes

This casserole is a star on its own, but if you’re looking to round out the meal, a crisp green salad with tangy vinaigrette is a refreshing counterpoint. Buttery garlic bread is another classic — those cheesy, saucy bites pair perfectly with a soft, toasted slab. If you’re in the mood for more Southern flair, consider a scoop of coleslaw or some roasted okra.

Creative Ways to Present

For family-style comfort, serve your Spicy Southern Cheesy Chicken Spaghetti Casserole right from the baking dish with a big serving spoon. Entertaining? Dish it out into ramekins or mini skillets for individual portions that feel extra special. You could even slice and reheat squares to tuck into a lunchbox or picnic thermos the next day — it’s just as crave-worthy on the go!

Make Ahead and Storage

Storing Leftovers

If you’re lucky enough to have leftovers, transfer cooled casserole to an airtight container and refrigerate for up to 4 days. The flavors actually deepen as it rests, so tomorrow’s lunch or dinner might taste even more comforting!

Freezing

Spicy Southern Cheesy Chicken Spaghetti Casserole freezes beautifully. Cut cooled portions, wrap tightly in foil and place in a freezer bag or container. It’ll keep for up to 2 months. For make-ahead magic, assemble but don’t bake — freeze the whole casserole, thaw overnight, then bake fresh for a just-made experience.

Reheating

To reheat, cover with foil and warm in a 350°F oven until hot and bubbling, 20-25 minutes (or a bit longer from frozen). Single servings can be microwaved in a pinch, just add a splash of broth or water to keep things moist and creamy.

FAQs

Can I use rotisserie chicken instead of cooking chicken breasts?

Absolutely! Rotisserie chicken is a fantastic shortcut if you’re pressed for time. Just shred about 2 cups and fold it into the casserole base — it will taste just as amazing and save you a step.

Can I swap the spaghetti for another pasta shape?

You sure can! While classic spaghetti gives this dish its signature texture, other long pastas like linguine or thin fettuccine work well. Even penne or rotini will soak up the sauce beautifully if that’s what you have on hand.

How do I make it even spicier?

If you’re craving more heat, add a diced jalapeño to the pepper mix, or increase the cayenne to 1 teaspoon. A little hot sauce stirred into the base or drizzled on top will also fire things up!

Is there a way to make this casserole gluten-free?

Yes! Simply substitute your favorite gluten-free spaghetti and check that your cream of chicken soup is certified gluten-free. All the other ingredients are naturally friendly for gluten-free diets.

Can I make Spicy Southern Cheesy Chicken Spaghetti Casserole ahead of time?

This casserole is totally make-ahead friendly. Assemble it up to a day in advance, cover, and refrigerate. When ready to bake, let it sit out while the oven preheats and then cook as directed — dinner will be on the table in no time!

Final Thoughts

If you’re ready for a dinner that’s bold, comforting, and guaranteed to get rave reviews, you have to try this Spicy Southern Cheesy Chicken Spaghetti Casserole. It’s become a go-to in my kitchen for good reason, and I just know you’ll be hooked on that perfect combo of creamy, spicy, and cheesy flavors from the very first bite. Enjoy!

Spicy Southern Cheesy Chicken Spaghetti Casserole Recipe

★★★★★

4.9 from 10 reviews

Author: Olivia
Total Time: 50 minutes
Yield: 6 servings 1x
Diet: Vegetarian

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Description

This Spicy Southern Cheesy Chicken Spaghetti Casserole brings together tender chicken, flavorful spices, and gooey cheddar cheese in a comforting casserole dish that’s perfect for family dinners or gatherings.

Ingredients

Scale

For the Casserole:

3–4 boneless, skinless chicken breasts (about 1.5 lbs)
8 oz spaghetti
2 cups shredded sharp cheddar cheese
1 cup fresh bell peppers (chopped)
1 can (10.5 oz) cream of chicken soup
1 tsp paprika
1/2 tsp cayenne pepper
1 tsp garlic powder
1/4 cup green onions (sliced)

Instructions

Preheat Oven: Preheat your oven to 350°F (175°C) and grease a large casserole dish.
Cook Chicken: Cook the chicken in a large pot over medium heat for about 6-7 minutes per side until golden and cooked through.
Cook Spaghetti: Boil salted water and cook spaghetti until al dente (8-10 minutes). Drain and set aside.
Prepare Casserole: In a bowl, mix shredded chicken, cooked spaghetti, cream of chicken soup, bell peppers, spices, and half of the cheddar cheese until well combined.
Bake: Transfer the mixture to the greased casserole dish, top with remaining cheese, and bake for 25-30 minutes until bubbly and golden brown.
Serve: Let it rest for 5 minutes, garnish with chopped green onions, and serve.